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Subtypes

There are three main histological subtypes of malignant mesothelioma: epithelioid, sarcomatous, and biphasic. Epithelioid and biphasic mesothelioma make up approximately 75-95% of mesotheliomas, and have been well characterized histologically, whereas sarcomatous mesothelioma has not been studied extensively. Most mesotheliomas express high levels of cytokeratin 5 regardless of subtype.

  1. Epithelioid mesothelioma is characterized by high levels of calretinin.
  2. Sarcomatous mesothelioma does not express high levels of calretinin.

Other morphological subtypes are:

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