There are three main histological subtypes of malignant mesothelioma: epithelioid, sarcomatous, and biphasic. Epithelioid and biphasic mesothelioma make up approximately 75-95% of mesotheliomas, and have been well characterized histologically, whereas sarcomatous mesothelioma has not been studied extensively. Most mesotheliomas express high levels of cytokeratin 5 regardless of subtype.
- Epithelioid mesothelioma is characterized by high levels of calretinin.
- Sarcomatous mesothelioma does not express high levels of calretinin.
Other morphological subtypes are:
- Clear cell
- Cartilaginous and osseous metaplasia
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